Four Conjoined Glass Bioreactor for Medium Optimization & High-Throughput Screening

The four conjoined glass bioreactor is a laboratory-scale glass fermentation system that is user-friendly, highly versatile, and capable of supporting multiple fermentation modes including batch, fed-batch, and even animal cell culture. A color touchscreen displays all measured values and control parameters, streamlining user operations significantly. Each tank is outfitted with 4 peristaltic pumps positioned adjacent to the front tank, delivering acid, alkali, antifoam agent, and culture medium to the fermentation vessel. The controller enables real-time monitoring of key fermentation parameters including pH, dissolved oxygen (DO), temperature, and agitation speed, with all data and control parameters transmissible to the controller or connected computer. Featuring a compact design, all system components are seamlessly integrated into the fermentation setup. Agitation is achieved via either upper-driven direct-coupling mechanical stirring or lower-driven magnetic indirect-coupling mechanical stirring, offering a simplified structure and consistent, stable performance.

Application areas:

• Identify secondary metabolites or novel enzymatic activities in heterogeneous mixed cultures;

• High-throughput screening studies, mutant strain distribution analysis and E. coli or yeast library construction;

• Metabolic flux analysis and high-throughput screening of high-activity mutant strains;

• Comparative studies, including clinical strain isolation and screening;

• Growth medium optimization for cell lines or high-yield strains;